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Article

A Synergistic Effect of Serotonin Transporter Gene Polymorphism and Smoking in Association with CHD

1 Jan 1999

Abstract excerpt

Serotonin induces vasoconstriction in the presence of atherosclerotic lesions. Platelets acquire serotonin from the extracellular space by serotonin transporter and release it following aggregation. There is a functional polymorphism in the serotonin transporter (5-HTT) gene promoter associated with transcriptional efficacy and plasma serotonin levels. To examine whether the polymorphism is associated with...

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PMID: 10404755
DOI: 10.1055/s-0037-1614586

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