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Article

Intestinal ganglioneuromatosis and multiple endocrine neoplasia type 2B: implications for treatment

1 Jul 1999

Abstract excerpt

Three infants, who presented with intestinal obstruction due to diffuse transmural intestinal ganglioneuromatosis, are described. Mutation analysis of exon 16 of the RET proto-oncogene revealed germline M918T and thus, a molecular diagnosis of multiple endocrine neoplasia type 2B (MEN 2B). Two infants developed medullary carcinoma of the thyroid. The third had a prophylactic thyroidectomy despite no obvious...

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Identifiers

PMID: 10369718
DOI: 10.1136/gut.45.1.143

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