[Globin gene mutation is a model of genetic abnormalities].

Abstract excerpt

Hemoglobin has been extensively studied as a prototype of molecular abnormality, and abnormal hemoglobins have disclosed a number of molecular pathogeneses. Genetic analysis of hemoglobin has also contributed to recent advances in molecular biology. Here, thalassemia (thal) is examined. It is a congenital type of hemolytic anemia caused by defective production of either alpha- or beta-globin due to various...

Topics

• Alu Elements
• Globins
• Humans
• Mutation
• Recombination, Genetic
• alpha-Thalassemia
• beta-Thalassemia