Article
Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2.
Microbiology (Reading, England) - 1 Mar 1999
Hohmann Stefan, Winderickx Joris, de Winde Johannes H, Valckx Dirk, Cobbaert Philip, Luyten Kattie, de Meirsman Catherine, Ramos José, Thevelein Johan M
Abstract excerpt
In the yeast Saccharomyces cerevisiae, glucose or fructose represses the expression of a large number of genes. The phosphorylation of glucose or fructose is catalysed by hexokinase PI (Hxk1), hexokinase PII (Hxk2) and a specific glucokinase (Glk1). The authors have shown previously that either Hxk1 or Hxk2 is sufficient for a rapid, sugar-induced disappearance of catabolite-repressible mRNAs (short-term...
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