Article
The odor specificities of a subset of olfactory receptor neurons are governed by Acj6, a POU-domain transcription factor.
Neuron - 1 Feb 1999
Clyne P J, Certel S J, de Bruyne M, Zaslavsky L, Johnson W A, Carlson J R
Abstract excerpt
Little is known about how the odor specificities of olfactory neurons are generated, a process essential to olfactory coding. We have found that neuronal identity relies on the abnormal chemosensory jump 6 (acj6) gene, originally identified by a defect in olfactory behavior. Physiological analysis of individual olfactory neurons shows that in acj6 mutants, a subset of neurons acquires a different odorant response...
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