Article
Familial Amyloidotic Polyneuropathy: domino liver transplantation.
Journal of hepatology - 1 Feb 1999
Schmidt H H, Nashan B, Pröpsting M J, Nakazato M, Flemming P, Kubicka S, Böker K, Pichlmayr R, Manns M P
Abstract excerpt
BACKGROUND/AIMS: The primary cause of Familial Amyloidotic Polyneuropathy is a variant transthyretin gene on chromosome 18. Progressive polyneuropathy followed by fatal cardiac and renal failure commonly manifest during middle age. Within 10 years after onset of clinical symptoms, affected individuals usually die due to malnutrition or heart failure. Currently, liver transplantation is the only available...
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