Article
Characterization of Moraxella (Branhamella) catarrhalis lbpB, lbpA, and lactoferrin receptor orf3 isogenic mutants.
Infection and immunity - 1 Mar 1999
Bonnah R A, Wong H, Loosmore S M, Schryvers A B
Abstract excerpt
Pathogenic members of the family Neisseriaceae produce specific receptors to acquire iron from their host's lactoferrin and transferrin. Recently, putative Moraxella catarrhalis lactoferrin receptor genes and a third open reading frame (lbpB, lbpA, and orf3) were cloned and sequenced. We describe the preliminary characterization of isogenic mutants deficient in LbpB, LbpA, or Orf3 protein.
Topics
- Bacterial Outer Membrane Proteins
- Blotting, Western
- Genes, Bacterial
- Iron
- Moraxella catarrhalis
- Mutation
- Open Reading Frames
- Receptors, Cell Surface
- Reverse Transcriptase Polymerase Chain Reaction