Article
Identification of DNA polymorphisms associated with the V type alpha1-antitrypsin gene.
Biochimica et biophysica acta - 16 Feb 1999
Gaillard M C, Mahadeva R, Lomas D A
Abstract excerpt
alpha1-Antitrypsin (alpha1-AT) is a highly polymorphic protein. The V allele of alpha1-AT has been shown to be associated with focal glomerulosclerosis (FGS) in Negroid and mixed race South African patients. To identify mutations and polymorphisms in the gene for the V allele of alpha1-AT in five South African patients with FGS nephrotic syndrome DNA sequence analysis and restriction fragment length polymorphisms...
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