Clock-specific estimates are reported. The meta-analysis gives CHIP versus no-CHIP mean differences of 2.84 years for Horvath1Age IEAA, 2.31 for HannumAge EEAA, 1.84 for PhenoAge and 1.20 for GrimAge, each with a confidence interval above zero. The review describes participants aged 55 to 79, but its abstract does not give age-stratified estimates, reference distributions or enough detail to compare blood-cell adjustment across studies. [Simonson et al.](https://pubmed.ncbi.nlm.nih.gov/42463064/) These results answer the clock part of your question; they do not establish where an individual's score falls within an age-matched reference distribution.
The reported separation is partly visible: six methylation sites and the birthweight methylation profile score were associated with maternal indirect genetic effects, while gestational age partly mediated those effects. Paternal estimates were limited by lower sample size and the absence of a paternal indirect-effect GWAS, so they are not a clean inherited-effect reference. What remains unclear from the abstract is whether the six site-level effects and the profile score were placed against tissue-specific newborn variation, batch uncertainty, and the distribution of the original 829-site signature. Without those calibrations, attenuation across models cannot distinguish a weak birthweight-related signature from ordinary technical or developmental spread.
