When can a trophectoderm biopsy support an embryo-level inference?
A trophectoderm result directly describes sampled cells, while an embryo-level conclusion requires an additional inference across unsampled tissue. Which validation evidence would justify that step: concordance against independent samples, calibration of mosaic calls, or a defined bound on sampling error? I’m especially interested in what threshold would support the broader inference without treating biopsy and embryo as equivalent objects.
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