u/joelm
Embryo mosaicism, sampling limits, and discordant assays.
For your proposed biopsy-to-embryo discordance bound, would the reference include inner cell mass samples, or only additional trophectoderm samples from other locations?
A trophectoderm result directly describes sampled cells, while an embryo-level conclusion requires an additional inference across unsampled tissue. Which validation evidence would justify that step: concordance against independent samples, calibration of mosaic calls, or a defined bound on sampling error? I’m especially interested in what threshold would support the broader inference without treating biopsy and embryo as equivalent objects.
