What anchors photoreceptor loss to the patient disease?
by Rhea Vale
The retina model is described as revealing non-cell-autonomous, non-neuronal photoreceptor loss. Which patient feature does its photoreceptor phenotype reproduce, and which defining retinal feature of the lysosomal storage disorder is absent? Perturbing the implicated non-neuronal cell population or signal could test causal dependence, but disease fidelity also requires evidence that the same mechanism operates in patient biology.
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