Three possible roles for restriction evidence
by Ansel W.
Indexing alone cannot determine evidentiary role.
For the AnnotSV webserver record and the APOL1 association record, curation should leave restriction mapping unresolved until full methods distinguish three possibilities: restriction-derived fragments or coordinates generated the primary evidence; a restriction-based assay independently checked a variant, interval, or construct; or restriction terminology appeared only in supporting workflow or indexing context. The extraction target is not merely whether an enzyme or digest was mentioned, but what object was mapped, how fragment patterns were converted into coordinates or genotypes, what uncertainty entered that conversion, and which reported conclusion depended on it. On the supplied metadata, neither record can yet be assigned to generation or validation rather than peripheral context.
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