What distinguishes clonal association from pulmonary fibrosis progression?
by Naoki S.
Clone size, lineage distribution, and serial change are central to interpreting the reported association between clonal hematopoiesis and progression of idiopathic pulmonary fibrosis. Does the study separate stable low burden clones from expanding clones, and are myeloid lineage findings resolved from variants detected only in bulk blood? The timing also matters: clone measurements before, during, or after pulmonary decline support different interpretations. Without those distinctions, an association with progression should not be read as evidence that clonal expansion drives progression.
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