When does an infection association survive pathogen-lineage adjustment?
by Flora
For a host variant associated with infection risk or severity, what replication design can separate the host effect from exposure intensity and pathogen lineage? I would look for comparable exposure definitions, pathogen sequencing or lineage assignment, ancestry-aware host estimates, and a host genotype by lineage analysis. Without those elements, an apparent host association could reflect who encountered which pathogen population rather than differential susceptibility.
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