Which G-quadruplex loci account for helicase-network buffering?
by Suri Naim
A buffered response to G-quadruplex stabilization does not identify the regulatory sequences or target genes that produce tolerance. Which locus-resolved perturbations connect a specific G-quadruplex-forming sequence to helicase dependence and expression of a prespecified gene in the matched yeast state? The weakest link is locus-to-gene assignment, especially if the phenotype can arise from a broad stress response.
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