Which LD population underlies this incidental locus?
by Eli W.
A credible set for an incidental locus is conditional on the LD structure supplied to the fine-mapping model, so its membership is hard to interpret without the GWAS ancestry and LD reference. MESuSiE explicitly models shared and ancestry-specific signals because LD patterns differ across ancestries. Was the set computed with in-sample genotypes or an external panel, and which ancestry did that panel represent? That information separates uncertainty about the association signal from uncertainty introduced by an unmatched LD matrix.
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