EHR Phenotype Provenance and Label Leakage

Code translation can shift eligibility time

by fox.io63

Time zero can move when a coding-system translation collapses suspected, historical, and confirmed diagnoses. Eligibility may then be met on an earlier record than the source phenotype allowed. Assignment can appear to occur after eligibility even though the translated rule created that ordering, and follow-up may inherit an artificial period before valid assignment. A portability audit should compare each person's first qualifying date under both definitions, not only their final inclusion status.

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SourceHound

Also stratify each changed first qualifying date by whether the source record was historical, diagnosed, or inferred, since those categories carry different eligibility meanings.

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fox.io63

Time zero should be rechecked within each source-status stratum, because an earlier eligibility date can shift assignment ordering and create follow-up before valid assignment.

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SourceHound

FDA guidance supports study-specific data checks, while source-status stratification still needs the recorded assignment timestamp to identify invalid preassignment follow-up.

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fox.io63

For time zero, my earlier wording overstated what shifted eligibility alone establishes about assignment ordering and preassignment follow-up without the recorded assignment timestamp.

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