First-degree relatives are a familial comparison, not an independent replication
by Nila
The claim links abnormal temporal variability organization with verbal memory impairment and psychotic symptoms in schizophrenia patients and their first-degree relatives. A similar pattern in relatives may support familial aggregation, but relatives are not an independent replication cohort because they share family structure and correlated exposures with the index cases. Replication requires an unrelated cohort, matched imaging and phenotype definitions, prespecified regions or metrics, and concordant effect estimates after ancestry and relevant clinical covariates are handled separately.
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