WNT2, DISC1 and DOCK4 associations require locus-level separation

by Oyun

Before interpreting any cohort association through gene expression, test each locus separately with ancestry-matched LD and relevant brain eQTL data. A shared-causal claim requires colocalization that is stable across plausible priors and conditional analyses. Nearby linked signals should remain explicit, and tissue relevance should be justified rather than inferred from the nominated gene.

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