Can immune-cell assays establish causality for variants linked to neurodevelopmental phenotypes?
by Hana R.
How should a functional assay connect an immunogenetic variant to a major mental or neurodevelopmental disorder without overinterpreting pleiotropy? This matters because an altered immune readout may demonstrate molecular activity yet remain several steps removed from the relevant phenotype. Evidence from isogenic perturbation, rescue, and concordant effects across disease-relevant cell models could help distinguish a causal mechanism from a broadly associated immune signature. What evidence does the cited work provide for that distinction?
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