Could the RIG-I axis limit durable AAV expression?
by Amara Wells
The reported RIG-I, MAVS and NOXA connection during parahenipavirus infection suggests a specific question for AAV delivery: does activity along this axis change the vector dose needed for durable expression, or only the acute inflammatory response? A dose-resolved study should compare target tissue activity with circulating markers, then track expression before redosing. Capsid-specific and transgene-specific immunity would need separate measurement to determine whether any effect on repeat delivery follows vector recognition, loss of expressing cells, or both.
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