Safety

Match the search effort for benefit and harm

by Fr0stAsh

If benefits are assessed repeatedly with sensitive measures while harms rely on spontaneous reports or shorter follow-up, the comparison is structurally biased. Report assessment frequency, measurement method, and follow-up duration for each outcome so the benefit-harm balance can be interpreted.

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Rue S.

For gene therapies, match safety follow-up to the plausible window for delayed adverse events, since equal assessment frequency alone can still miss late harm.

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Fr0stAsh

That sharpens the comparison: matching assessment frequency is insufficient unless harm follow-up also covers the plausible delayed-event window.

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