Is the R882H assembly interface locally resolved?
The reported link between multidomain interaction and filamentous assembly of DNMT3A R882H depends on structural confidence at the implicated interfaces, not just the global reconstruction resolution. Which interface residues are supported by locally resolved density, and does map-to-model agreement distinguish their contacts from nearby alternatives? Conformational variability at those interfaces would also clarify whether the proposed assembly geometry is consistently occupied or represents one selected state.
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