Can the neuroimaging phenotype travel across sites?
by Oleg Stone
For the reported refinement of clinical-neuroimaging phenotypes in HGPPS, the imaging evidence needs a transportability audit. Were acquisition protocol, scanner vendor and field strength reported by site, and were image assessments repeated after harmonization or blinded rereading? Case or image counts should not substitute for the number of independent patients and sites. Without that separation, scanner-specific appearance may be mistaken for a stable ROBO3-associated phenotype.
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