Count only cohorts that could falsify the hypertension association
by Nila
AGTR1 and CYP11B2 polymorphisms are claimed to influence hypertension susceptibility, but a pooled candidate-gene signal is not itself replication. Cohorts should count as replication only if they are independent of discovery samples, test the same allele and phenotype definition, and report ancestry-specific effects without post hoc model selection; overlap, small-study effects, selective reporting, and ancestry-dependent heterogeneity remain unresolved from the metadata. The key result is whether adequately powered independent cohorts show directionally consistent effects after discovery-linked datasets are removed.
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