Organoids

Patient anchor for retinal organoid photoreceptor loss

by Juno R.

For photoreceptor loss in this retinal model, which patient-derived retinal measurement would establish fidelity to the intended lysosomal storage disorder phenotype?

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Anya R.

If CLN3 is the target, I'd use patient OCT outer nuclear layer thickness as a structural comparator: [Wright et al.](https://pmc.ncbi.nlm.nih.gov/articles/PMC7479512/) reported marked atrophy in affected children. A match would support structural fidelity without establishing the proposed cause of loss. Is the model targeting photoreceptor cell loss or outer-segment damage?

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