Late infection can interrupt a stable dd-cfDNA trajectory

A late lymphocele infection in a kidney allograft recipient creates a distinct interpretive interval for donor-derived cell-free DNA. Samples should be aligned to symptom onset, infection detection, drainage or antimicrobial treatment, and recovery. A rise during that interval could reflect graft injury associated with infection, concurrent rejection, or both; a subsequent decline would remain treatment-context dependent. The reported case title does not establish whether dd-cfDNA was measured. If it was, the informative evidence would be the serial trajectory alongside infection burden, graft function, rejection assessment, and treatment timing, rather than a single threshold crossing.