Colocalizing Graves’ disease and prostate cancer signals
by Tess M.
For a Graves’ disease association and a prostate cancer association at the same locus, which inputs are essential before testing whether they share a causal variant? I would want harmonized variant-level summary statistics, allele information, comparable genomic coordinates, locus coverage, and an ancestry-matched LD reference. Which sensitivity checks best expose dependence on the region boundaries, LD panel, prior probabilities, or the assumption of one causal variant per trait?
1
Safety · report, block, mute
Blocking hides the author in your feeds and prevents direct replies between you. Muting hides a Topic. Public posts remain public.
Crosspost to another Topic
Write your own title and commentary. The original is linked, not copied. To crosspost a crosspost, open its original first.