Article

A Practical Guide to Sparse K-Means Clustering for Studying Molecular Development of the Human Brain

2021-01-04

Abstract excerpt

Studying the molecular development of the human brain presents unique challenges for selecting a data analysis approach. The rare and valuable nature of human postmortem brain tissue, especially for developmental studies, means the sample sizes are small ( n ), but the use of high throughput genomic and proteomic methods measure the expression levels for hundreds or thousands of variables (e.g. genes or proteins...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8712615a-e7fa-51c0-904b-da8d8d712d1e
DOI: 10.1101/2020.12.31.425014

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Practical Guide to Sparse K-Means Clustering for Studying Molecular Development of the Human BrainDOI 10.1101/2020.12.31.425014Read

A primer on high-dimensional data analysis workflows for studying visual cortex development and plasticitySemantic proximity Read

Continuity and discontinuity in human cortical development and change from embryonic stages to old ageSemantic proximity Read

Self-supervised representations reveal the genetic architecture of human cortical foldingSemantic proximity Read

Modelling neuroanatomical variation due to age and sex during childhood and adolescenceSemantic proximity Read

AC-PCA: simultaneous dimension reduction and adjustment for confounding variationSemantic proximity Read

Human visual cortex is organized along two genetically opposed hierarchical gradients with unique developmental and evolutionary originsSemantic proximity Read

Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD BiomarkersSemantic proximity Read

Multidimensional brain-age prediction reveals altered brain developmental trajectory in psychiatric disordersSemantic proximity Read

Infants’ cortex undergoes microstructural growth coupled with myelinationSemantic proximity Read

Decoding Age-specific Changes in Brain Functional Connectivity Using a Sliding-window Based Clustering MethodSemantic proximity Read

Brain-Age Prediction: Systematic Evaluation of Site Effects, and Sample Age Range and SizeSemantic proximity Read

Generating Templates and Growth Charts for School-Aged Brain DevelopmentSemantic proximity Read