Article

DNA damage repair factor TOP1 induces tumor-promoting inflammation and PD-L1 production via a cGAS-dependent manner during cervical cancer development

2023-09-06

Abstract excerpt

<title>Abstract</title> <p>Cervical carcinogenesis is regulated by DNA damage repair (DDR) and inflammation. The DDR protein topoisomerase I (TOP1) has been implicated in various cancers due to its role in regulating genome stability. Recent studies have revealed that TOP1 regulates the anti-inflammatory response and TOP1 inhibition protects cells from COVID-19-induced death. However, the specific functions and m...

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Literature Corpus work: 79ed21a1-7c06-5949-8797-bbb52c4387c0
DOI: 10.21203/rs.3.rs-3213446/v1

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