Article

Exploring the use of synthetic placebo populations in ALS randomized clinical trials

2022-12-13

Abstract excerpt

<h4>Objectives</h4> The use of synthetic data to supplement clinical trial placebo groups or for trial planning is rapidly gaining interest. However, there is not yet an established framework for generating synthetic data for these purposes. In this work we test two approaches to generating synthetic placebo arms for ALS trials with survival being the primary outcome variable. <h4>Methods</h4> For the first approa...

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Literature Corpus work: 3ceecfb3-19ef-5572-aa80-56d0db514d2f
DOI: 10.1101/2022.12.09.22283281

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