Article

Evidence for the major role of PH4αEFB in the prolyl 4-hydroxylation of <i>Drosophila</i> collagen IV

2025-08-06

Abstract excerpt

Collagens are fundamental components of extracellular matrices, requiring precise intracellular post-translational modifications for proper function. Among the modifications, prolyl 4-hydroxylation is critical to stabilise the collagen triple helix. In humans, this reaction is mediated by collagen prolyl 4-hydroxylases (P4Hs). While humans possess three genes encoding these enzymes (P4H⍺s), Drosophila melanogaste...

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Literature Corpus work: 1233ce85-9272-51b8-9382-c8c6526f6813
DOI: 10.1101/2025.08.05.668786

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