Article
Frequent occurrence of hypoalphalipoproteinemia due to mutant apolipoprotein A-I gene in the population: a population-based survey.
Human molecular genetics - 1 Feb 1999
Yamakawa-Kobayashi K, Yanagi H, Fukayama H, Hirano C, Shimakura Y, Yamamoto N, Arinami T, Tsuchiya S, Hamaguchi H
Abstract excerpt
To determine the frequency of familial hypoalphalipoproteinemia in the general population due to mutation of the apolipoprotein A-I (apo A-I) gene, we analyzed sequence variations in the apo A-I gene. The subjects were 67 children with a low high-density lipoprotein (HDL) cholesterol level (</=38...
Topics
- Adolescent
- Amino Acid Sequence
- Apolipoprotein A-I
- Base Sequence
- Child
- Cholesterol
- Cholesterol, HDL
- DNA
- DNA Mutational Analysis
- Female
- Humans
- Hypolipoproteinemias
- Male
- Mutation
- Polymorphism, Genetic