Article
Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator).
Biochemistry - 2 Feb 1999
Ramjeesingh M, Li C, Garami E, Huan L J, Galley K, Wang Y, Bear C E
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) functions as an ATPase and as a chloride channel. It has been hypothesized, on the basis of electrophysiological findings, that the catalytic activity of CFTR is tightly coupled to the opening and closing of the channel gate. In the p...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Alanine
- Catalysis
- Chloride Channels
- Cystic Fibrosis Transmembrane Conductance Regulator
- Humans
- Ion Channel Gating
- Lysine
- Mutation
- Protein Folding