Article
Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.
The Journal of clinical endocrinology and metabolism - 1 Jan 1999
Gadelha M R, Prezant T R, Une K N, Glick R P, Moskal S F, Vaisman M, Melmed S, Kineman R D, Frohman L A
Abstract excerpt
Familial acromegaly/gigantism occurring in the absence of multiple endocrine neoplasia type I (MEN-1) or the Carney complex has been reported in 18 families since the biochemical diagnosis of GH excess became available, and the genetic defect is unknown. In the present study we examined 2 unrelat...
Topics
- Acromegaly
- Adolescent
- Adult
- Child
- Chromosomes, Human, Pair 11
- Female
- Gigantism
- Humans
- Loss of Heterozygosity
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Mutation
- Neoplasm Proteins
- Proto-Oncogene Proteins