Article
Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.
The Journal of clinical endocrinology and metabolism - 1 Jan 1999
Gadelha M R, Prezant T R, Une K N, Glick R P, Moskal S F, Vaisman M, Melmed S, Kineman R D, Frohman L A
Abstract excerpt
Familial acromegaly/gigantism occurring in the absence of multiple endocrine neoplasia type I (MEN-1) or the Carney complex has been reported in 18 families since the biochemical diagnosis of GH excess became available, and the genetic defect is unknown. In the present study we examined 2 unrelated families with isolated acromegaly/gigantism. In family A, 3 of 4 siblings were affected, with ages at diagnosis of...
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