Article
Localization of a gene for familial hemophagocytic lymphohistiocytosis at chromosome 9q21.3-22 by homozygosity mapping.
American journal of human genetics - 1 Jan 1999
Ohadi M, Lalloz M R, Sham P, Zhao J, Dearlove A M, Shiach C, Kinsey S, Rhodes M, Layton D M
Abstract excerpt
Familial hemophagocytic lymphohistiocytosis (FHL), also known as familial erythrophagocytic lymphohistiocytosis and familial histiocytic reticulosis, is a rare autosomal recessive disorder of early childhood characterized by excessive immune activation. Linkage of the disease gene to an approximately 7.8-cM region between markers D9S1867 and D9S1790 at 9q21.3-22 was identified by homozygosity mapping in four...
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