The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.

doi:10.1016/s0022-3476(99)70379-3

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Article

The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.

The Journal of pediatrics - 1 Jan 1999

Stacpoole P W, Bunch S T, Neiberger R E, Perkins L A, Quisling R, Hutson A D, Greer M

Abstract excerpt

In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean +/- SEM difference between these variables was 2.4 +/- 0.3 mmol/L (P =.0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid la...

Topics

Acidosis, Lactic
Adolescent
Adult
Child
Child, Preschool
DNA, Mitochondrial
Electron Transport
Female
Humans
Infant
Lactates
Male
Mutation
Pyruvate Dehydrogenase Complex Deficiency Disease

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