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Article

The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects.

American journal of respiratory cell and molecular biology - 1 Jan 1999

Smith S N, Middleton P G, Chadwick S, Jaffe A, Bush K A, Rolleston S, Farley R, Delaney S J, Wainwright B, Geddes D M, Alton E W

Abstract excerpt

Previous studies have indicated that milrinone, a specific type III phosphodiesterase inhibitor, may be able to induce chloride secretion in cystic fibrosis (CF) tissues. We have now assessed the effect of this agent in vivo on the nasal epithelium of CF mutant mice and also in the nose and lungs of human subjects with CF. Wild-type mice showed a small hyperpolarization of the nasal potential difference (PD) in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9870926
DOI: 10.1165/ajrcmb.20.1.3278

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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