Article
The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects.
American journal of respiratory cell and molecular biology - 1 Jan 1999
Smith S N, Middleton P G, Chadwick S, Jaffe A, Bush K A, Rolleston S, Farley R, Delaney S J, Wainwright B, Geddes D M, Alton E W
Abstract excerpt
Previous studies have indicated that milrinone, a specific type III phosphodiesterase inhibitor, may be able to induce chloride secretion in cystic fibrosis (CF) tissues. We have now assessed the effect of this agent in vivo on the nasal epithelium of CF mutant mice and also in the nose and lungs...
Topics
- Amiloride
- Animals
- Chlorides
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Epithelium
- Humans
- Isoproterenol
- Lung
- Male
- Membrane Potentials
- Mice
- Milrinone
- Mutation
- Nose
- Phosphodiesterase Inhibitors