Article
Search for a founder mutation in idiopathic focal dystonia from Northern Germany.
American journal of human genetics - 1 Dec 1998
Klein C, Ozelius L J, Hagenah J, Breakefield X O, Risch N J, Vieregge P
Abstract excerpt
Both the discovery of the DYT1 gene on chromosome 9q34 in autosomal dominant early-onset torsion dystonia and the detection of linkage for one form of adult-onset focal dystonia to chromosome 18p (DYT7) in a family from northern Germany provide the opportunity to further investigate genetic facto...
Topics
- Age of Onset
- Aged
- Alleles
- Carrier Proteins
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 9
- Dystonia
- Dystonia Musculorum Deformans
- Female
- Founder Effect
- Gene Frequency
- Germany
- Heterozygote
- Humans
- Linkage Disequilibrium
- Male
- Meige Syndrome
- Middle Aged