Article
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998
Nichols K E, Harkin D P, Levitz S, Krainer M, Kolquist K A, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler A J, Wise C, Ashley J, Lovett M, Valentine M B, Look A T, Gerald W, Housman D E, Haber D A
Abstract excerpt
X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein-Barr virus (EBV). In affected males, primary EBV infection leads to the uncontrolled proliferation of virus-containing B cells and reactive cytotoxic T cells, often cu...
Topics
- Amino Acid Sequence
- Chromosome Mapping
- Genetic Linkage
- Genetic Markers
- Humans
- Lymphoproliferative Disorders
- Molecular Sequence Data
- Mutation
- X Chromosome
- src Homology Domains