Article
Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients.
Clinical chemistry and laboratory medicine - 1 Aug 1998
Wirta V, Huang X H, Wirta O, Rantalaiho V, Pasternack A, Jokela H, Koivula T, Lehtimäki T
Abstract excerpt
The missense mutation in the 677th nucleotide (C677T) of methylenetetrahydrofolate reductase gene causes substitution of valine (V) for alanine (A) resulting in three genotypes VV, VA and AA. The VV genotype causes hyperhomocysteinemia and may be a risk factor for coronary artery disease. We determined genotypes by polymerase chain reaction and subsequent restriction fragment length analysis and compared them in...
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