Article
Tertiary structure-dependence of misfolding substitutions in loops of the maltose-binding protein.
Protein science : a publication of the Protein Society - 1 Oct 1998
Raffy S, Sassoon N, Hofnung M, Betton J M
Abstract excerpt
We previously identified and characterized amino acid substitutions in a loop connecting helix I to strand B, the alphaI/betaB loop, of the N-domain that are critical for in vivo folding of the maltose-binding protein (MalE31). The tertiary context-dependence of this mutation in MalE folding was assessed by probing the tolerance of an equivalent alphabeta loop of the C-domain to the same amino acid substitutions...
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