Article
Human EGFR, a candidate gene for the Silver-Russell syndrome, is biallelically expressed in a wide range of fetal tissues.
European journal of human genetics : EJHG - 1 Jan 2000
Wakeling E L, Abu-Amero S N, Stanier P, Preece M A, Moore G E
Abstract excerpt
Maternal uniparental disomy of chromosome 7 (mUPD7) has been reported in around 10% of cases of Silver-Russell syndrome (SRS). This suggests that at least one gene on chromosome 7 is imprinted and involved in the pathogenesis of this condition. One candidate is epidermal growth factor receptor (E...
Topics
- Abnormalities, Multiple
- Alleles
- Aneuploidy
- Animals
- Cells, Cultured
- Child
- Child, Preschool
- Chromosomes, Human, Pair 7
- ErbB Receptors
- Fetus
- Gene Expression
- Genomic Imprinting
- Humans
- Mice
- Polymorphism, Restriction Fragment Length
- Syndrome