Article
Use of the C3H/He Lyme disease mouse model for the recovery of a Spanish isolate of Borrelia garinii from erythema migrans lesions.
Research in microbiology - 1 Jan 1998
Oteo J A, Backenson P B, del Mar Vitutia M, García Moncó J C, Rodríguez I, Escudero R, Anda P
Abstract excerpt
A skin biopsy from a patient with erythema migrans was inoculated into C3H/He mice and into culture medium. A Borrelia garinii strain named Rio1 was isolated from both a direct BSK medium culture and a mouse ear-punch biopsy culture. Inoculating human tissue into mice produced a disease resulting in severe inflammation of the left tibio-tarsal joint, development of perivascular infiltrates as seen in ear-punch...
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