What we know and what we do not know about cystic fibrosis transmembrane conductance regulator.

doi:10.1016/s0272-5231(05)70093-9

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Article

What we know and what we do not know about cystic fibrosis transmembrane conductance regulator.

Clinics in chest medicine - 1 Sept 1998

Ma J, Davis P B

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel that resides in the apical membrane of many epithelial cells. Channel opening requires phosophorylation of serine residues in an intracellular regulatory domain by protein kinase A and as the bindi...

Topics

Amino Acid Sequence
Chloride Channels
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Humans
Ion Channel Gating
Membrane Proteins
Mutation
Phosphorylation

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