Article
What we know and what we do not know about cystic fibrosis transmembrane conductance regulator.
Clinics in chest medicine - 1 Sept 1998
Ma J, Davis P B
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel that resides in the apical membrane of many epithelial cells. Channel opening requires phosophorylation of serine residues in an intracellular regulatory domain by protein kinase A and as the binding and hydrolysis of ATP by intracellular nucleotide binding domains. Besides conducting the chloride ion, CFTR also...
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