Article
Familial hyperaldosteronism type II: description of a large kindred and exclusion of the aldosterone synthase (CYP11B2) gene.
The Journal of clinical endocrinology and metabolism - 1 Sept 1998
Torpy D J, Gordon R D, Lin J P, Huggard P R, Taymans S E, Stowasser M, Chrousos G P, Stratakis C A
Abstract excerpt
Familial hyperaldosteronism type II (FH-II) is characterized by autosomal dominant inheritance and hypersecretion of aldosterone due to adrenocortical hyperplasia or an aldosterone-producing adenoma; unlike FH type I (FH-I), hyperaldosteronism in FH-II is not suppressible by dexamethasone. Of a t...
Topics
- Aldosterone
- Blotting, Southern
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- Cytochrome P-450 CYP11B2
- Dexamethasone
- Female
- Genotype
- Humans
- Hyperaldosteronism
- Lod Score
- Male
- Middle Aged
- Pedigree
- Polymerase Chain Reaction
- Potassium
- Renin