Article
Dominant optic atrophy: exclusion and fine genetic mapping of the candidate gene, HRY.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 1998
Votruba M, Payne A, Moore A T, Bhattacharya S S
Abstract excerpt
Autosomal dominant optic atrophy (OPA1) maps to Chromosome (Chr) 3q28, and the disease interval has been refined to within 1.4 cM, flanked by the markers D3S3669 and D3S3562. HRY, the human homolog of the Drosophila segmentation gene, hairy, maps by in situ hybridization to the chromosomal region...
Topics
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Case-Control Studies
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- DNA Primers
- Dinucleotide Repeats
- Drosophila
- Drosophila Proteins
- Exons
- Female
- Genes, Dominant
- Genes, Insect
- Haplotypes
- Humans
- Insect Proteins
- Male