Article
Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease.
Molecular cell - 1 Aug 1998
Watnick T J, Torres V E, Gandolph M A, Qian F, Onuchic L F, Klinger K W, Landes G, Germino G G
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD), Type I is a common genetic disorder and an important cause of renal failure. The disease is characterized by progressive cyst formation in a variety of organs including the kidney, liver and pancreas. We have previously shown that in the case...
Topics
- Base Sequence
- Cysts
- DNA
- DNA Primers
- Humans
- Liver Diseases
- Loss of Heterozygosity
- Models, Genetic
- Mutation
- Polycystic Kidney, Autosomal Dominant
- Polymerase Chain Reaction