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Article

Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease.

Molecular cell - 1 Aug 1998

Watnick T J, Torres V E, Gandolph M A, Qian F, Onuchic L F, Klinger K W, Landes G, Germino G G

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD), Type I is a common genetic disorder and an important cause of renal failure. The disease is characterized by progressive cyst formation in a variety of organs including the kidney, liver and pancreas. We have previously shown that in the case of PKD1, renal cyst development is likely to require somatic inactivation of the normal allele coupled to a germline...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9734362
DOI: 10.1016/s1097-2765(00)80135-5

Genes

PKD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease.PMID 9734362Read ↗

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A "two-hit" model of cystogenesis in autosomal dominant polycystic kidney disease?Semantic proximity Read ↗

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