Article
Genomic structure of the human congenital chloride diarrhea (CLD) gene.
Gene - 3 Jul 1998
Haila S, Höglund P, Scherer S W, Lee J R, Kristo P, Coyle B, Trembath R, Holmberg C, de la Chapelle A, Kere J
Abstract excerpt
Congenital chloride diarrhea (CLD) is caused by mutations in a gene which encodes an intestinal anion transporter. We report here the complete genomic organization of the human CLD gene which spans approximately 39kb, and comprises 21 exons. All exon/intron boundaries conform to the GT/AG rule. A...
Topics
- Base Sequence
- Chlorides
- Cloning, Molecular
- DNA
- DNA Primers
- Diarrhea
- Exons
- Genome, Human
- Humans
- Introns
- Ion Transport
- Metabolism, Inborn Errors
- Molecular Sequence Data
- Multigene Family
- Mutation
- Polymerase Chain Reaction
- Promoter Regions, Genetic